NMN Research Highlights in 2024: Revealing new advances in anti-aging and disease treatment, not to be missed!
In 2024, the research field of NMN (niacinamide mononucleotide) ushered in a number of breakthroughs, which not only deepened our understanding of the mechanism of action of NMN, but also provided new directions for future clinical applications.
Alleviating effect of NMN on high-fat diet-induced aging
In October 2024, a study published in The Journal of Nutrition revealed the potential of nicotinamide mononucleotide (NMN) to mitigate the aging effects caused by a high-fat diet (HFD).
The study put 14-month-old mice on a high-fat diet for seven months with 400mg/kg of NMN added to the water.
The results showed that NMN significantly increased the levels of nicotinamide adenine dinucleotide (NAD+) in mice, effectively combating the physiological decline caused by aging and a high-fat diet.
Specifically, NMN supplementation significantly enhanced the physical activity capacity of mice, improved glycolipid metabolism, and significantly improved skeletal muscle function.
NMN has also been shown to improve kidney damage, aging, and inflammatory conditions.
These results suggest that NMN supplementation may have a positive effect on alleviating metabolic disorders and physiological decline induced by high fat diet.
As a potential anti-aging intervention, NMN’s potential to ameliorate health problems associated with a high-fat diet warrants further study and exploration.
Potential role of NMN in the treatment of Alzheimer’s disease
In October 2024, a study published in the journal Cell Death & Disease indicated that niacinamide mononucleotide (NMN) has a positive effect on improving Alzheimer’s disease (AD).
In the study, the researchers genetically engineered mice to carry genes associated with the heritability of Alzheimer’s disease in humans.
The transgenic mice were treated with injections of 500 mg of NMN daily for two months.
The experimental results revealed that NMN significantly improved the memory loss symptoms of AD model mice and effectively inhibited synaptic destruction.
Synapses are key structures for neurons to connect, communicate and form memories, and their integrity is crucial for cognitive function.
NMN enhances mitochondrial stress response by activating the NAD+-UPRmt pathway, which is of great significance for improving mitochondrial homeostasis in AD-associated cell models
These findings further confirm the potential of NMN in the treatment of Alzheimer’s disease and provide a scientific basis for future studies exploring NMN in humans to improve AD symptoms.
Ameliorative effect of NMN on male reproductive disorders
In October 2024, research published in Acta Biochimica et Biophysica Sinica revealed the potential efficacy of nicotinamide mononucleotides (NMN) in improving ionizing radiation-induced testicle damage and seminal dysfunction in adult male mice.
The team built a mouse model to simulate damage to the reproductive system caused by ionizing radiation through a single whole-body gamma-ray exposure, and then treated the model mice with a dose of 500mg/kg of NMN
The results showed that NMN significantly improved the sperm quality and motility of mice, and reduced the damage of testis caused by ionizing radiation.
Specifically, NMN supports mitochondrial function by enhancing the availability of NAD+, optimizing the production of ATP necessary for sperm motility.
The antioxidant properties of NMN help reduce oxidative stress, which can damage sperm DNA and impair fertility.
By reducing oxidative stress, NMN helps maintain sperm integrity and function.
The study further confirms the positive regulatory role of NMN in improving male reproductive disorders caused by ionizing radiation, providing a scientific basis for NMN as a potential treatment.
Improvement of dietary induced liver fat by NMN
On May 3, 2024, a study published in Biomedicine & Pharmacotherapy revealed a significant improvement in beta-nicotinamide mononucleotide (NMN) against liver steatosis in mice caused by a high-fat diet (HFD).
The study found that NMN not only reduced weight gain, reduced fasting blood glucose levels, and enhanced glucose tolerance in mice on a high-fat diet, but also reduced fat accumulation in liver cells by regulating intracellular metabolic pathways, promoting efficient processing and breakdown of fat.
Specifically, NMN activates metabolic pathways associated with fatty acid beta oxidation, tricarboxylic acid (TCA) cycling, and valine degradation by increasing NAD+ levels.
Activation of these metabolic pathways helps to improve lipid metabolism in the liver and reduce fat accumulation in the liver.
NMN supplementation has also been found to regulate liver protein acetylation, a post-translational modification of proteins associated with aging that plays a critical role in regulating the aging process and age-related diseases.
Analysis of NMN clinical trial results in Top three hospitals
On April 27, 2024, at the LEGEND Vascular Symposium 2024 and Spring Symposium of Vascular Medicine Specialty Committee of Chinese Pathophysiological Society, The Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital) has announced the results of China’s first human trial of anti-aging NMN (niacinamide mononucleotide) led by a third-class hospital.
The study was a Phase II clinical study involving 40 healthy participants in a randomized, double-blind, placebo-controlled trial design.
Participants received 300 mg of NMN daily during the 60-day trial.
The results showed that subjects supplemented with NMN showed a significant reduction in biological age compared to the placebo group.
The specific improvement shown in:
Seventy percent of participants reported a decrease in daily fatigue, 60 percent reported a decrease in daily blood pressure monitoring, 55 percent reported an increase in motor function, 40 percent reported an improvement in sleep quality, and 30 percent reported an increase in appetite.
The successful unblinding of this trial marks that China has officially entered the clinical evidence-based stage in the field of NMN research, and provides strong clinical data support for the potential of NMN as an anti-aging intervention.
Potential efficacy of NMN in ALS
In March 2024, a study published in the journal Antioxid Redox Signal showed that NMN can directly act on motor neurons to improve motor function in ALS models.
NMN promotes neuronal growth and prevents cell death caused by nutrient deprivation, providing a new perspective for the treatment of ALS.
Effects of NMN on cellular senescence and immune regulation
On January 15, 2024, a research team at Harbin Medical University announced its latest research results in the field of aging biology, which delve into the complex links between aging, tumor microenvironment, mitochondrial function and the immune system.
Studies have found that NMN supplementation can significantly increase the concentration of NAD+ in senescent cells, thereby inhibiting the activity of STING signaling pathway, improving the senescence state of T cells, and reducing the secretion of inflammatory mediators.
This study provides a new molecular mechanism for understanding the role of NMN in cell aging and immune regulation, suggesting that NMN may counteract age-related immune function decline and inflammatory response by regulating key signaling pathways, and provides a scientific basis for the development of anti-aging interventions.
