NMN, full name of nicotinamide mononucleotide, is a compound naturally occurring in the human body and commonly found in fruits and vegetables, and its main role is to synthesize NAD+.
The level of NAD+ decreases with age, and NMN supplementation can increase its level and improve metabolism and cell health.
Many celebrities such as entertainment stars, academics, and business leaders began to recommend NMN and share their use experience, such as Justin Bieber and Hayley couple, supermodel Ken Dou, Buffett, Li Ka-shing, Pan Shiyi, Harvard professor David Sinclair, etc., celebrities led β-Nicotinamide Mononucleotide to be more and more well-known by the public.
In 2024, four major NMN research results
In 2024, NMN has achieved a number of major achievements in the field of scientific research, which covers reproductive health, anti-aging, neurodegenerative diseases and many other aspects.
Reproductive health
Professor Rong Chen’s team at Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, and Professor Peng Zhang’s team at Children’s National Medical Center/Beijing Children’s Hospital affiliated to Capital Medical University found that NMN supplementation significantly increased serum estrogen levels, reduced follicle-stimulating hormone levels, and increased anti-Mulerian hormone levels in older people mice, suggesting that β-Nicotinamide Mononucleotide improved ovarian hormone secretion.
anti-aging
A study by the Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences found that supplementing NMN can improve the level of NAD+, save the small intestine aging caused by mitochondrial DNA mutation, and regulate intestinal flora, increase the abundance of beneficial bacteria and reduce the abundance of harmful bacteria.
Chinese Geriatric Clinical Expert Consensus on Anti-Aging Drug Intervention Research (2024) wrote NMN into the consensus as a scientific anti-aging strategy, which has the potential to prevent disability and improve fatigue in the older people.
Neurodegenerative disease
The research team at Wenzhou Medical University found that NMN supplementation significantly improved mitochondrial protein toxicity, reduced hippocampal synaptic destruction, reduced neuron loss, and improved brain atrophy in mice.
Human trial
On April 27, 2024, Shanghai Changzheng Hospital, the Second Affiliated Hospital of Naval Medical University, announced the unblinding results of the anti-aging NMN human trial conducted by China’s first first-class hospital.
According to the subjective feelings of the subjects, 40% of the people had improved sleep quality, 30% increased appetite, 55% improved motor function, 70% reduced daily fatigue, 60% reduced daily blood pressure monitoring levels, and 45% decreased blood sugar monitoring levels.
NMN, improve our mitochondrial function!
NMN is a substance that plays a significant role in mitochondrial function.
As a direct precursor of NAD+, β-Nicotinamide Mononucleotide can improve mitochondrial work efficiency, activate enzymes to restore mitochondrial protein function, and promote mitochondrial regeneration and repair.
NMN can also regulate the activity of proteins related to mitochondrial dynamics and improve mitochondrial morphology and function.
At the same time, it can reduce the free radicals produced by mitochondria, activate DNA repair enzymes, and protect mitochondria from damage.
NMN can regulate the expression of mitochondria-related genes and maintain the young state of mitochondria.
A recent study in Japan found that NMN can inhibit hearing loss
Japanese scientists have found that NMN supplementation can prevent age-related hearing loss in mice.
NMN improves hearing by the following mechanisms:
First, improve the level of NAD +, maintain the normal function of inner ear cells, and ensure sound signal transmission and processing;
Second, to enhance cellular energy metabolism, NMN-transformed NAD + supplies energy to inner ear cells, helps sound signal conversion, and restores hearing damaged by energy metabolism disorders;
Third, play an antioxidant role, activate antioxidant enzymes, clear ROS in the inner ear, reduce oxidative damage, and protect the inner ear cells.
Taking NMN can make a person energetic
First, increase the level of NAD +, enhance cell productivity, and enhance mitochondrial function;
The second is to activate Sirtuins protein family, adjust the biological clock, enhance the ability of cells to resist stress;
The third is to promote blood vessel health and blood circulation, and supply energy to tissues.
NMN is not only a “new star” in the current supplement market, but its application prospects in many industries also make it an important part of the future health industry.
