NAD+ works with stem cells to fight aging. Do you know the science behind it?
NAD+ combined with stem cells to become a golden anti-aging partner!
Aging is the natural law of life, as we grow older, our bodies will gradually show various signs of aging.
Skin loses elasticity, wrinkles appear, body function decreases, and the risk of various chronic diseases increases.
Aging is not only a change in appearance, but also a gradual decline in the function of cells and organs inside the body.
In 1896, the first time humans opened the door to stem cells, a paper in the field of cell biology found that “stem cells are more early cells capable of producing daughter cells.”
However, as living cells, after a long time in vitro culture of stem cells, their original precision localization ability will gradually decline.
With this in mind, a research team from the State Key Laboratory of East China University of Science and Technology, published in antioxidants, found that NAD+ helps maintain the functional lifespan of stem cells and improves the effectiveness of stem cell therapies.
At the same time, NAD+ can also promote stem cell migration, reduce stem cell damage, and prevent stem cell aging.
What are stem cells?
A cell must have two abilities in order to be called a stem cell. One is “self-replication,” that is, the ability to reproduce and divide into cells with the same function as its own.
The second is “super differentiation”, the ability to differentiate into epidermal cells, red blood cells, platelets and other cells in the body.
At the same time, stem cells can help slow the aging process and improve the body’s metabolic function by replacing aging or damaged cells.
In short, stem cells are like our body’s “universal repairers”, they can precisely repair the broken “house” (i.e. the various tissues and organs of the body).
Whether it’s a leaky roof (damaged organs) or a broken wall (aging cells), stem cells can quickly “fill the place” and restore the health and vitality of the body with their exquisite skills.
So how do you ensure that stem cells continue to function as desired after transplantation into the human body?
NAD+ synergistic therapy provides a new strategy for it!
Relationship between NAD+ and stem cells
1. NAD+ restores stem cell viability
To study the effects of NAD+ on stem cells, the scientists isolated a type of stem cell from the maternal umbilical cord.
Of these, umbilical cord stem cells are the most commonly used for treatment (second only to bone marrow stem cells) because they are easy to obtain and do not cause much of an immune response when injected into the body.
After experiments, the researchers found that the cultured stem cells produced 67 percent more reactive oxygen species, and NAD+ promoted the growth of stem cells.
2. NAD+ enhances stem cell migration
Because stem cells are needed to locate the injured tissue site for the treatment to work, the researchers tested the effect of NAD+ on stem cell migration, which increased by three times.
The results show that NAD+ can enhance the homing effect of stem cells for stem cell therapy.
3. NAD+ prolongs stem cell replication life
After exposing the stem cells to hydrogen peroxide (H2O2) for two hours, the researchers found that about 86 percent of the stem cells entered a state of cell damage and senescence, while NAD+ prevented the stem cells from entering a state of senescence.
The findings suggest that NAD+ can extend the replication lifetime of cultured stem cells, increasing the potential for stem cell therapeutic efficacy.
conclusion
Stem cell therapy has successfully entered the field of practice from the theoretical stage, and has aroused wide attention and enthusiasm in the world.
With its unique homing mechanism and excellent repair ability, stem cells have become a powerful weapon in the treatment of many diseases.
NAD+ has previously shown to enhance the role of stem cells in treating heart disease repair, so research to strengthen NAD+ as a stem cell therapy is growing.
reference
Zheng Z, Wang X, Ouyang L, et al. Antioxidants Improve the Proliferation and Efficacy of hUC-MSCs against H2O2-Induced Senescence. Antioxidants (Basel). 2023 Jun 24;12(7):1334.
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