People spend 1/3 of their life in sleep, and sleep very important to human health. This also because sleep closely related to the body immunity, cognition and metabolism. NMN
Therefore, the researchers speculate that the age-related decline in sleep quality may cause the occurrence of aging-related diseases.
With age, researchers have found that the secretion of melatonin and total cortisol hormones will gradually decrease at night, resulting in a decrease in rapid eye movement (dream) and deep sleep time, thereby affecting sleep quality. Research in this direction is of great significance to the growing population of middle-aged and older people.
According to different biological signals, we can divide the sleep process into three stages: wakefulness, rapid eye movement (REM) and non-rapid eye movement (NREM). In the non-rapid eye movement period, it can be subdivided into four states (N1-N4). As people age, the time spent in REM, N3, and N4 states will gradually decrease. After the age of 60, the N4 state will disappear, resulting in a significant increase in the frequency of nighttime awakenings.
For now, although drugs for insomnia can solve the problem, there are more or less side effects such as drowsiness and obesity. How to solve sleep problems in a better way has become an important topic for relevant researchers in the future . Due to the anti-aging properties of NMN, it also became the first batch of research objects.
Recently, the research team of Southern University of Science and Technology published an article in the “American Journal of Translational Medicine”. They conducted clinical trials on 58 middle-aged and older people, and proved that NMN can significantly shorten the time to fall asleep, increase the time of rapid eye movement and deep sleep, and improve sleep quality.
According to the data in the table, we found that there was no significant difference in the total PSQI score and sleep latency between the NMN group and the control group before treatment, but there was a significant difference after treatment, especially the total PSQI score. Compared with the control group, the total PSQI score decreased more in the NMN group, which means that the volunteers had better sleep quality after NMN treatment.
As far as the group is concerned, there are significant differences in the total PSQI score, sleep quality, sleep latency, sleep disturbance and daytime dysfunction in the control group before and after treatment, which may be caused by the placebo effect; the total PSQI score in the NMN group before and after treatment , sleep quality, sleep latency, and daytime dysfunction were significantly different.
Furthermore, improving sleep quality in older adults may be just one of the many benefits of NMN in alleviating age-related diseases. Unraveling the further benefits of NMN will require a large number of clinical trials, including neurological, cardiovascular and metabolic aspects.
