As early as December 2013, Professor David Sinclair of Harvard Medical School published a research result in the international authoritative journal “Cell”, stating that “after increasing the NAD+ content in cells with NMN for one week, the lifespan of mice was extended by 30%.”
This is the first public confirmation that the NAD+ precursor NMN can reverse aging and extend lifespan. The research shocked the world and has since placed NMN in the leading position in the field of aging inhibition and intervention.
From being overly deified to returning to a scientific lifestyle, NMN has gradually come into the public eye for consumption.
Up to now, the three major international authoritative journals, Nature, Science and Cell, have published over 100 reports related to NMN and its metabolite NAD+.
These reports have shown that NMN has significant effects in delaying aging, repairing DNA damage, regulating metabolism and protecting the heart.
NMN (Nicotinamide Mononucleotide, abbreviated as NMN), also known as nicotinamide mononucleotide, is a substance that naturally exists in the human body.
From a molecular perspective, it is a ribonucleotide and the basic structural unit of genetic material RNA.
Structurally speaking, it is composed of nicotinamide groups, ribose and phosphate groups.
NMN is converted into NAD+ (Nicotinamide Adenine Dinucleotide, also known as nicotinamide adenine dinucleotide) within cells, thereby exerting its functions.
NMN can be directly converted into NAD+ (nicotinamide adenine dinucleotide), and it is more easily absorbed and utilized by cells.
NMN supplements have become the top choice for increasing NAD+ levels in the body.
NAD+ can also activate a group of Sirtuins proteins known as “longevity proteins”, regulating their gene expression, thereby reducing the occurrence of diseases and delaying the aging process.
Just as David Sinclair said, “As people age, the concentration of NAD+ in the human body gradually decreases. The resulting reduction in the activity of longevity proteins is the main cause of diseases in humans during the aging process.”
During the aging process, naturally increasing the level of NAD+ within cells may be able to slow down or reverse certain aging processes.
The NAD+ in the body gradually decreases after the age of 25.
This is why we often hear people say that the aging process accelerates after the age of 25, and middle-aged and older people are not as physically and energetic as they were when they were young.
The safety of NMN as a dietary supplement has been scientifically confirmed in the latest clinical studies and human experiments.
top ten benefits of NMN
01 Helps delay aging
NAD+ (coenzyme I) can maintain the chemical communication between the cell nucleus and mitochondria.
If this communication weakens, it will lead to mitochondrial decline, and mitochondrial decline is an important factor in cellular aging.
NAD+ (coenzyme I) can maintain the normal expression of genes, sustain the specific functions of cells, and slow down the process of cells transforming into senescent cells.
02 Science and Technology News
The core pathological mechanism of diabetes is the defect in insulin secretion.
When pancreatic beta cells damaged and insulin is relatively insufficient, the body’s sugar metabolism will unbalanced, thereby triggering the disease.
Studies have shown that NMN can improve the disorder of glycolipid metabolism from multiple aspects by enhancing the sensitivity of insulin receptors, increasing the uptake and utilization of glucose by target organs, and promoting the activity of key enzymes in fat mobilization and gluconeogenesis, thereby playing a potential role in preventing diabetes.
03 Helps prevent cardiovascular and cerebrovascular diseases
Clinical studies on arteriosclerosis and related cardiovascular diseases have shown that oxidation of low-density lipoprotein is an important inducible of arteriosclerosis.
NMN exerts a protective effect on the cardiovascular system through the following mechanisms:
Increasing the level of high-density lipoprotein, inhibiting the oxidation of low-density lipoprotein, alleviating the inflammatory response of macrophages, reducing the formation of atherosclerotic plaques, enhancing the stability of plaques to lower the risk of rupture, and ultimately improving the blood flow condition of blood vessels through multiple pathways, thereby playing a role in the prevention and treatment of cardiovascular diseases.
04 Helps enhance immunity
NMN can achieve multi-pathway immunomodulatory effects by promoting the secretion of spleen cell antibodies, activating T cell function and enhancing the synthesis of immunoglobulins.
05 Helps prevent cancer
Experiments have proved that NMN has definite anti-cancer properties, and its effects reflected in:
The activity of liver transferase induced is significantly stronger than that of β -carotene.
By countering the carcinogenic effect of aflatoxin B1, it effectively inhibits the proliferation of liver tumor cells, specifically manifested as a reduction in the number of tumors and a decrease in the volume of lesions.
06 helps prevent hypertension
NMN mainly inhibits and reverses atherosclerosis by supplementing NAD+,
gradually restoring foam cells to smooth muscle cells of blood vessels, thereby restoring vascular elasticity.
At the same time, it prevents the re-formation of blood clots through anti-inflammatory effects,
thereby unblocking blocked collateral circulation and increasing blood volume, thus continuously and slowly lowering blood pressure.
07 Maintain the regenerative capacity of capillaries
When muscle cells are in motion, they release growth factors. After receiving these growth factors, the epidermal cells of capillaries accelerate their growth. This process relies on the longevity protein Sirtuin1 generated by NAD+ (coenzyme I).
The older a person is, the less NAD+ (coenzyme I) they have in their body,
and the worse the stimulating effect of exercise on muscle growth.
08 Promote alcohol metabolism
Alcohol metabolism is divided into two steps. First, its converted into toxic acetaldehyde, and then further decomposed into harmless acetic acid. Each step must rely on the catalysis of coenzyme I.
09 Helps protect eyesight
The human retinoid and central nervous system are rich in unsaturated fatty acids,
and the free radicals produced by oxidation can easily cause peroxidation damage to them.
Research has found that NMN can easily pass through the blood-brain barrier and cell membranes,
effectively preventing retinal oxidation and protecting the central nervous system,
especially the brain, thereby effectively treating central nervous system injuries such as spinal cord injuries,
Parkinson’s syndrome, and Alzheimer’s syndrome.
Especially in the treatment of macular degeneration of the retina, its effect is more significant than that of lutein.
10 Improve Sleep
Supplementing NMN can increase the level of NAD+ in the body, and NAD+ is closely related to the biological clock.
The interaction between NAD+ and the biological clock reflected in the fact that the metabolism of NAD+ regulated by the biological clock, and in turn, it also affects the biological clock.
For people who lack sleep and have irregular schedules,
increasing the level of NAD+ in the body can help regulate the biological clock and restore its normal circadian rhythm.
For older people who have regular sleep but a decline in sleep quality,
the accelerated loss of NAD+ due to aging will reduce the gene expression of the biological clock and make it less adaptable.
At this time, supplementing NMN can adjust the inherent cycle of the biological clock and enhance its adaptability.
This is also the reason why many older people have improved sleep quality and are more likely to sleep through the night after taking NMN.
